oude vrouw in rolstoel krijgt hulp van zuster
Are you a

Healthcare professional?

Do you work with patients or clients with swallowing problems? Is the intake of medication often a battle? Do you have to come up with all kinds of tricks to get the medication administered?

Since a couple of years Gloup is on the market. It is a registered medical device that helps many people with taking their medication in a safe way. Of course we understand that you as a healthcare professional want to have more information and data showing you the safety of a product like Gloup. Our products are all based on clinical and scientific data about medication administration, safety and interactions.

In your current practice

Try to avoid

The use of fruit juices/apple sauce for the administration of medication:

  • Fibers have a negative impact on a number of medication [3,4,5,6].
  • Bioflavonoïds in fruit have a negative impact on certain medication [7].
In your current practice

Try to avoid

The use of dairy products for medication administration:

  • Decreases the effect of lots of different medication [8] .
  • Decreases the absorption of specific medication [9].
In your current practice

Try to avoid

Crushing medication/opening capsules:

  • Can decrease effectiveness and stability of medication and increase toxicity [10].
  • Increased risk of health issues for healthcare professionals because of increased toxic effects via inhalation and skin exposure. [10].
In your current practice

Try to avoid

The use of food thickeners for the intake of medication:

  •  Decreases the absorption of different medication dramatically [14].
  • Xanthan Gum and gom en Guar Gum have a huge impact on the absorption of medication [15].

Gloup: the safe choice

  • Registered Medical Device Class 1
  • Patented formulation
  • Use of Gloup: 48% ease of use, 34% decrease crushing and 33% increased therapy loyalty [13].
  • Studied in multiple ways by The University of Queensland (UQ)/ School of Pharmacy Brisbane/Australië [11, 12, 13].
  • Use of food thickeners: Decreases absorption of different medication dramatically [14].
  • Xanthan Gum en Guar Gum have huge impact on absorption of medication [15].
  • Queensland University classifies Gloup Original and Zero as IDDSI level 3 (room temperature) and Level 4 (from fridge) [12].
  • Queensland University classifies Gloup Forte as only genuine IDDSI Level 4 swallowing aid available.
  • Decreases the need to crush up to 40% [11].
Gloup

Why?

Because food has not been developed for the intake of medication, it is not the best choice. Gloup has been specifically designed for the intake of medication and is a medical device. It is helping people that face problems with swallowing oral medication. Gloup is a gel that covers the pill and makes the pill slide down the throat easily. Gloup masks the bitter taste of the medication and does not effect the effectiveness of the medication administered. It is a registered medical device class 1, designed and improved in collaboration with different universities around the world.

  • Gloup Forte
  • Gloup Original
  • Gloup Zero
  • Gloup Kids

How to use Gloup

  • 1. Let the patient try Gloup first without any medication;
  • 2. Start with just 1 tablet and expand to multiple tablets per intake later;
  • 3. Put the tablet(s) on a spoon;
  • 4. Put Gloup on top so the medication is fully covered (not too much);
  • 5. Offer the spoon to the patient for intake;
  • 6. After the intake with Gloup a glass of water can be taken but that is not necessary;
  • 7. Gloup Forte: First put some Gloup on a spoon, than add the tablet and put some Gloup on top;
  • 8. Gloup can be used with both entire and crushed tablets. Always check at the pharmacy whether the medication is allowed to be crushed;
  • 9. Crushed medication: First put some Gloup in a medicine cup, than add the crushed medication and put some Gloup on top. Finally spoon it up entirely and offer it to the patient;
  • 10. It might happen that the administration of medication with Gloup is not successful the first time. Please keep in mind that he/she has to get used to the texture of the gel, because this is the first time he/she swallows medication with a gel. Try multiple times and it will definitely improve;
  • 11. Because Gloup is slippery, there is a huge chance that less crushing is necessary as Gloup eases swallowing the entire tablet. It is always best practice not to crush if not needed!

Sources

1. Carnaby-Mann, G. and Crary, M. Pill swallowing by adults with dysphagia. Archives Otolaryngology Head and Neck Surgery. Nov 2005:131(11):970-975.
2. McCabe-Sellers B., Frankel E.H., Wolfe J. “Handbook of Food-Drug Interactions.” Boca Raton, FL: CRC Press. 2003; 12: 262-266.
3. Brown DD, Juhl RP, Warner SL. Decreased bioavailability of digoxin due to hypocholesterolemic interventions. Circulation.1978 Jul;58(1):164-72. PMID: 647881
4. Gaby AR, Batz F, Chester R, et al. A-Z Guide to drug-herb-vitamin interactions. Revised and expanded 2nd edition. Three Rivers Press. 2006. ISBN: 03-07336-64-6
5. Liel Y, Harman-Boehm I, Shany S. Evidence for a clinically important adverse effect of fiber-enriched diet on the bioavailability of levothyroxine in adult hypothyroid patients. J Clin Endocrinol Metab. 1996 Feb;81(2):857-9. PMID: 8636317
6. Moreyra AE, Wilson AC, Koraym A. Effect of combining psyllium fiber with simvastatin in lowering cholesterol. Arch Intern Med. 2005 May 23;165(10):1161-6. PMID: 15911730
7. Lilja, J.J., Juntti-Patinen, L. & Neuvonen, P.J. Orange juice substantially reduces the bioavailability of the beta‑adrenergic-blocking agent celiprolol. Clin.Pharmacol. Ther. 75, 184–190 (2004).
8. Gaby AR, Batz F, Chester R, et al. A-Z Guide to drug-herb-vitamin interactions. Revised and expanded 2nd edition. Three Rivers Press. 2006. ISBN: 03-07336-64-6
9. Food-Drug Interactions Rabia Bushra, Nousheen Aslam, Arshad Yar Khan Rabia Bushra Nousheen Aslam College of Pharmacy Ziauddin college of Pharmacy, Ziauddin University, Karachi, Pakistan. E-mail: rabia_pharmacist@hotmail.com Arshad Yar Khan Dept. of Chemistry University of Karachi, Pakistan. Received: 17 Oct 2010 / Accepted: 09 Dec 2010 © OMSB, 2011
10. SHPA Carol simmons, medicines information pharmacist, Fremantle Hospital and health service, WA. Article don’t rush to crush.
11. Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam–probes of CYP2C9, CYP1A2, and CYP3A4. Clin Pharmacol Ther. 2007 Jun;81(6):833-9. Epub 2007 Mar 28. PMID: 17392729
12. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll Nutr  1994 Dec;13(6):584-91. PMID: 7706591
13. Khor SP, Hsu A. The pharmacokinetics and pharmacodynamics of levodopa in te treatment of Parkinson’s disease. Curr Clin Pharmacol 2007 Sep;2(3):234-43. PMID: 18690870
14. Crushed Tablets: Does the Administration of Food Vehicles and Thickened Fluids to Aid Medication Swallowing Alter Drug Release? Yady J. Manrique1, Danielle J. Lee1, Faiza Islam1, Lisa M. Nissen1,2 , Julie A.Y. Cichero1, Jason R. Stokes3, Kathryn J. Steadman1 1 School of Pharmacy, The University of Queensland, Brisbane, Qld 4072, Australia. Published, May 1, 2014
15. Thickening agents used for dysphagia management: effect on bivailability of water, medication and feelings of satiety. Julie AY Chichero Nutricional Journal 201312:54, DOI:10.1186/1475-2891-1254.